Pyrimidine nucleosides

One-carbon nitrogen ring bases (thymine and cytosine covalently linked to a sugar (ribose or deoxyribose); can function as extracellular messengers, antimetabolites, and chain terminators that inhibit viral DNA polymerase.

Search Within Results

241 – 255 of 292 results

241

Apexbio Technology LLC 5-BrdU(Synonyms: Bromodeoxyuridine, BrdU, 5-Bromo-2'-deoxyuridine, 5-Bromodeoxyuridine), 1g, CAS: 59-14-3.

5-Bromo-2 -deoxyuridine (5-BrdU CAS 59-14-3) is a thymidine analog that integrates into DNA during S-phase of cell division Its incorporation facilitates immunodetection via specific monoclonal or polyclonal antibodies In vitro studies show that early application of 5-BrdU to Nicotiana glauca pith explants inhibits cellular proliferation an effect reversed by addition of thymidine or deoxycytidine In vivo BrdU immunostaining identifies proliferating neuronal cells in mouse central nervous system tissues paralleling earlier thymidine labeling studies Thus 5-BrdU serves as a molecular tool for analyzing cell cycle progression and neurogenesis in biomedical research

Pricing & Availability

242

eMolecules 951-77-9 | ChemScene | 2-Deoxycytidine | 5g | 536774267 | CS-0010105 | MFCD23103479 | 227.22 | C9H13N3O4

ChemScene | 2-Deoxycytidine | 5g | 536774267 | CS-0010105 | 951-77-9 | MFCD23103479 | 227.220 | C9H13N3O4

Pricing & Availability

243

Cayman Chemical 3′-Deoxyuridine, Purity: ≥98%, CAS: 7057-27-4, 100 mg

A dehydroxylated derivative of uridine; inhibits uridine phosphorylase isolated from T. gondii (apparent Ki = 2.459 mM); decreases the proliferation of CCRF CEM, L1210, P388, and S180 cancer cells (EC50s = 25, 5, 2.5, and 15 µM, respectively); reduces the infection rate and number of T. cruzi amastigotes in HeLa cells at 1 µM; induces sodium currents in X. laevis oocytes expressing human CNT 1 or CNT 3 at 500 µM

Pricing & Availability

244

Cayman Chemical 2'-Fluoro-2'-deoxyuridine, Purity: ≥98%, CAS: 784-71-4, 25 mg

A derivative of uridine; hepatitis C polyU/UC RNA strands containing 2'-FdU bind to RIG-I but do not activate RIG-I signaling in a reporter assay using Huh7 cells; has been used as a starting material in the synthesis of RSV polymerases inhibitors

Pricing & Availability

245

Cayman Chemical 5-Formyl-2'-deoxyuridine, Purity: ≥95%, CAS: 4494-26-2, 50 mg

A nucleoside derivative; inhibits the proliferation of BHK-21 cells and Ehrlich ascites tumor cells (IC50s = 4 and 6 µM, respectively); reduces virus yield in psuedorabies-infected BHK-21 cells at 1 mM; a product of oxidative DNA damage in vitro

Pricing & Availability

246

eMolecules 951-78-0 | 2'-Deoxyuridine | ChemScene | MFCD00006527 | 228.204 | C9H12N2O5 | 98.000 | OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O | 25g | 572244290

2'-Deoxyuridine | ChemScene | 951-78-0 | MFCD00006527 | 228.204 | C9H12N2O5 | 98.000 | OC[C@H]1O[C@H](C[C@@H]1O)n1ccc(=O)[nH]c1=O | 25g | 572244290

Pricing & Availability

247

Apexbio Technology LLC 2-Deoxycytidine,1g CAS# 951-77-9

2-Deoxycytidine is a cytidine analog [1]. 2-Deoxycytidine prevents DNA methylation by incorporating itself into newly synthesizing DNA strand. 2-Deoxycytidine also binds to DNA methyltransferase irreversibly and hinders its activity. Thus, 2-deoxycytidine was approved as the most efective demethylating agent for the treatment of cancer [1]. 2-Deoxycytidine at clinically achievable and nontoxic concentrations (≥ 100 μmol/L) protected normal bone marrow progenitor cells against the inhibitory effects of co-administered, high concentrations of 3’-azido-3’-deoxythymidine (AZT) (≥ 10 μmol/L). In normal bone marrow mononuclear cells (BMMC), 2-deoxycytidine also significantly corrected AZT-mediated depletion of intracellular thymidine triphosphate and 2-deoxycytidine triphosphate levels. Furthermore, 2-deoxycytidine reduced the intracellular accumulation of AZT triphosphate and its DNA incorporation in BMMC [2]. Other sizes are also available. Please inqury us for quote.

Pricing & Availability

248

Sigma Aldrich Fine Chemicals Biosciences Fialuridine >=98% (HPLC) | 69123-98-4 | MFCD00866922 | 5MG

Pricing & Availability

249

Sigma Aldrich Fine Chemicals Biosciences 3'-Azido-3'-deoxythymidine >=98% (HPLC) | 30516-87-1 | MFCD00006536 | 100MG

Pricing & Availability

250

Medchemexpress LLC 2'-Deoxyuridine (Standard) | 951-78-0 | 99.2% | 25 MG

2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine, intended for research and analytical applications. It is a brain-penetrant pyrimidines nucleotide associated with nervous system diseases. It can increase chromosome breakage and decrease thymidylate synthetase activity. It reduces microglial activation and improves oxidative stress damage by modulating glycolytic metabolism on Aβ25-35-induced brain injury, showing promise for Alzheimer's disease (AD) research.

Used as an analytical standard.
Precursor in the synthesis of Edoxudine.
Analogue of 5-ethynyl-2'-deoxyuridine.
Reduces microglial activation.
Improves oxidative stress damage.
Promising for Alzheimer's disease research.
Utilized in HPLC, GC, and MS research experiments.

Pricing & Availability

251

Medchemexpress LLC 2'-Deoxyuridine 5'-monophosphate disodium | 42155-08-8 | CB9482517 | 100.0% | 352.15 | 250 MG

2'-Deoxyuridine 5'-monophosphate disodium (dUMP disodium) is a deoxynucleotide and an endogenous metabolite. It is reductively methylated to dTMP, a nucleotide essential for DNA synthesis. This compound exhibits anti-bacterial activity against *Helicobacter pylori* by inhibiting HpThyX enzyme activities. It is provided as a solid, white to off-white in color, and is intended for research use only.